Osteoporosis & Fractures & Bone Metabolism
The importance of Calcium
Bone healing, inhibition, and regeneration activities in osteoporosis all require a healthy absorption and bioavailability of calcium and a proper balance between osteoclasts and osteoblasts (bone building and degrading cells, respectively). The importance of calcium for bone density and strength is well known and accepted by the general public, but it is also particularly important to balance of calcium level in the blood system for maintaining healthy functioning of most of the body cells.
ACC for Better Absorption of Calcium
Nevertheless, calcium is not absorbed well via food and supplement consumption, especially as people become older. Compared to crystalline calcium carbonate (CCC), the primary calcium supplement on the market, the stabilized Amorphous Calcium Carbonate (ACC) has demonstrated double or higher absorption in the body in two clinical studies. This higher absorption rate means significantly better absorption in the body for ACC compared to any other leading calcium supplements.
Better Bioavailability by ACC
In addition to its exceptional high absorption rate, ACC has demonstrated a 30 to 50% higher bioavailability in the form of bone building and restoration, as indicated in two preclinical studies. The studies exhibited higher bone density and strength in preclinical rat models for osteoporosis. These findings are frequently corroborated by the positive feedback of Density® consumers, who suffer from osteoporosis, fractures, and other bone-related diseases.
The higher bioavailability of the ACC indicates enhanced activity, attributed to the pH modulation associated with controlled dissolution of ACC at an injured or mal-functioning organ, which releases both calcium and basic carbonate ions, hence activating their crucial roles. ACC showed faster and healthier proliferation and differentiation of Mesenchymal Stem Cells into osteoblasts and osteoclasts (mature bone cells) in in-vitro studies, compared to CCC or similar concentrations of calcium ions. ACC’s improved performance was even repeated in a microgravity experiment, performed at the space station. Space conditions are known to significantly inhibit the osteoblasts’ performance, causing astronauts to lose 1 to 2% of their bone mass per month.
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Bone Loss Prevention In Ovariectomized Rats Using Stable Amorphous Calcium Carbonate
Amorphical has shown an increase in calcium bioavailability in rats administered with synthetic, stable Amorphous Calcium Carbonate (ACC) in comparison to crystalline calcium carbonate (CCC). This study sought to see whether the superior bioavailability indeed manifests improved bone mass density in an animal osteoporosis model. The study compared the effects of stabilized ACC derived from either Cherax quadricarinatus gastrolith or synthesized ACC with those of CCC or calcium citrate found in commercial calcium supplements.
Study results
1. Administration of natural or synthetic ACC helped prevent bone loss more than the CCC and calcium citrate. This conclusion was based on Micro Computed Tomography (µCT) of each rat group’s bone structure as well as on markers in urine.
2. The ACC administered groups were the only ones showing significant increase in the strength of osteoporotic weakened
bones. The strength increase was even more significant with synthetic ACC than with the natural gastrolith ACC. The article authors concluded that these were a medical breakthrough, as such level of bone loss prevention had never been previously reported. The study findings indicate ACC’s high potential for preventing metabolic bone disorders such as osteoporosis.
“Bone loss prevention in ovariectomized rats using stable amorphous calcium carbonate”,
Shltiel, G., Bar-David, E., Meiron, O.E., Waltman, E., Shechter, A., Aflalo, E.D., Stepensky, D., Berman, A., Martin, B.R. & Weaver, C.M, Health 5, 18-29 (2013). Health http://dx.doi.org/10.4236/health.2013.57A20033